RRAGA/B Antibody

Catalog Number:

34965

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q7L523/Q5VZM2
NCBI Gene ID: 10670/10325

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human RRAGA/B.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total RRAGA/B protein.

Applications:

WB

Background:

Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.

Schuermann A., J. Biol. Chem. 270:28982-28988(1995).
Li Y., J. Virol. 71:1576-1582(1997).
Hirose E., J. Cell Sci. 111:11-21(1998).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF