AKR1A1 Antibody

Catalog Number:

34395

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P14550
NCBI Gene ID: 10327

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from C-terminal of human AKR1A1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total AKR1A1 protein.

Applications:

WB

Background:

Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).

Bohren K.M., J. Biol. Chem. 264:9547-9551(1989).
Fujii J., Cytogenet. Cell Genet. 84:230-232(1999).
Barski O.A., Genomics 60:188-198(1999).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF