CMKLR1 Antibody

Catalog Number:

34201

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q99788
NCBI Gene ID: 1240

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human CMKLR1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CMKLR1 protein.

Applications:

WB

Background:

Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).

Methner A., Biochem. Biophys. Res. Commun. 233:336-342(1997).
Samson M., Eur. J. Immunol. 28:1689-1700(1998).
Hillman R.T., Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF