CENPA Antibody

Catalog Number:

34199

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P49450
NCBI Gene ID: 1058

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human CENPA.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CENPA protein.

Applications:

IHC

Background:

Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).

Sullivan K.F., J. Cell Biol. 127:581-592(1994).
Hillier L.W., Nature 434:724-731(2005).
Shelby R.D., J. Cell Biol. 136:501-513(1997).

References:

appl_detail:

Immunohistochemistry: 1:50~1:100

Datasheet PDF