H-NUC Antibody

Catalog Number:

34190

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P30260
NCBI Gene ID: 996

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human H-NUC.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total H-NUC protein.

Applications:

WB

Background:

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Tugendreich S., Proc. Natl. Acad. Sci. U.S.A. 90:10031-10035(1993).
Chen P.L., Cell Growth Differ. 6:199-210(1995).
Kraft C., EMBO J. 22:6598-6609(2003).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF