CARD11 Antibody

Catalog Number:

34184

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9BXL7
NCBI Gene ID: 84433

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human CARD11.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CARD11 protein.

Applications:

WB

Background:

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.

Bertin J., J. Biol. Chem. 276:11877-11882(2001).
Gaide O., FEBS Lett. 496:121-127(2001).
Hillier L.W., Nature 424:157-164(2003).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF