CDH23 Antibody

Catalog Number:

34179

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9H251
NCBI Gene ID: 64072

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human CDH23.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CDH23 protein.

Applications:

IF

Background:

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.

Bolz H., Nat. Genet. 27:108-112(2001).
Clark H.F., Genome Res. 13:2265-2270(2003).
Bork J.M., Am. J. Hum. Genet. 68:26-37(2001).

References:

appl_detail:

Immunofluorescence: 1:100~1:500

Datasheet PDF