Ik3-1 Antibody

Catalog Number:

34172

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q8TDN4
NCBI Gene ID: 91768

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human Ik3-1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total Ik3-1 protein.

Applications:

WB

Background:

Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death By similarity.

Ota T., Nat. Genet. 36:40-45(2004).
Nusbaum C., Nature 437:551-555(2005).
Wu C.-L., Cancer Res. 61:7325-7332(2001).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF