14-3-3 β Antibody

Catalog Number:

34144

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P31946
NCBI Gene ID: 7529

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human 14-3-3 β.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total 14-3-3 β protein.

Applications:

WB

Background:

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.

Leffers H., J. Mol. Biol. 231:982-998(1993).
Deloukas P., Nature 414:865-871(2001).
Gevaert K., Nat. Biotechnol. 21:566-569(2003).
Chi A., J. Proteome Res. 5:3135-3144(2006).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF