SPIN1 Antibody

Catalog Number:

34139

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9Y657
NCBI Gene ID: 10927

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human SPIN1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total SPIN1 protein.

Applications:

WB

Background:

Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.

Zhang H.L., Chin. Sci. Bull. 45:909-914(2000).
Gao Y., Biochem. Biophys. Res. Commun. 335:343-350(2005).
Humphray S.J., Nature 429:369-374(2004).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF