CLK4 Antibody

Catalog Number:

34070

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9HAZ1
NCBI Gene ID: 57396

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human CLK4.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CLK4 protein.

Applications:

WB

Background:

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.

Schultz J., Genomics 71:368-370(2001).
McNally T., Protein Sci. 12:1562-1566(2003).
Kantham L., Biochem. Biophys. Res. Commun. 304:125-129(2003).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF