ACTR-1C Antibody

Catalog Number:

33973

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q8NER5
NCBI Gene ID: 130399

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human ACTR-1C.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total ACTR-1C protein.

Applications:

IHC IF

Background:

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

Bondestam J., Cytogenet. Cell Genet. 95:157-162(2001).
Roberts H.J., Biol. Reprod. 68:1719-1726(2003).
Hillier L.W., Nature 434:724-731(2005).

References:

appl_detail:

Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500

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