NFIL3 Antibody

Catalog Number:

33913

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q16649
NCBI Gene ID: 4783

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human NFIL3.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total NFIL3 protein.

Applications:

WB

Background:

Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts By similarity. Represses transcriptional activity of PER1 By similarity. Represses transcriptional activity of PER2 via the B-site on the promoter By similarity. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) By similarity. Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock By similarity. Protects pro-B cells from programmed cell death By similarity.

Cowell I.G., Mol. Cell. Biol. 12:3070-3077(1992).
Zhang W., Mol. Cell. Biol. 15:6055-6063(1995).
Humphray S.J., Nature 429:369-374(2004).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF