IRF4 Antibody

Catalog Number:

33893

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q15306
NCBI Gene ID: 3662

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human IRF4.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total IRF4 protein.

Applications:

WB

Background:

Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes By similarity.

Grossman A., Genomics 37:229-233(1996).
Iida S., Nat. Genet. 17:226-230(1997).
Mungall A.J., Nature 425:805-811(2003).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF