E2F2 Antibody

Catalog Number:

33877

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q14209
NCBI Gene ID: 1870

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human E2F2.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total E2F2 protein.

Applications:

WB

Background:

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner.

Ivey-Hoyle M., Mol. Cell. Biol. 13:7802-7812(1993).
Gregory S.G., Nature 441:315-321(2006).
Novy M., Mol. Biol. Cell 16:2181-2190(2005).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF