TNAP1 Antibody

Catalog Number:

33873

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q13829
NCBI Gene ID: 7126

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human TNAP1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total TNAP1 protein.

Applications:

WB

Background:

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.

Wolf F.W., J. Biol. Chem. 267:1317-1326(1992).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Nousiainen M., Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF