CaMK2β/γ Antibody

Catalog Number:

33871

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q13555/Q13554
NCBI Gene ID: 818/816

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from C-terminal of human CaMK2β/γ.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CaMK2β/γ protein.

Applications:

WB

Background:

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in sarcoplsamic reticulum Ca2+ transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.

Deloukas P., Nature 429:375-381(2004).
Breen M.A., Biochem. Biophys. Res. Commun. 236:473-478(1997).
Tombes R.M., Biochim. Biophys. Acta 1355:281-292(1997).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF