MED21 Antibody

Catalog Number:

33869

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q13503
NCBI Gene ID: 9412

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human MED21.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total MED21 protein.

Applications:

IHC

Background:

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Chao D.M., Nature 380:82-85(1996).
Maldonado E., Nature 381:86-89(1996).
Oelgeschlaeger T., Mol. Cell 1:925-931(1998).

References:

appl_detail:

Immunohistochemistry: 1:50~1:100

Datasheet PDF