TPD52 Antibody

Catalog Number:

33823

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P55327
NCBI Gene ID: 7163

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human TPD52.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total TPD52 protein.

Applications:

IHC

Background:

a coiled-coil motif bearing hydrophilic protein known to be overexpressed in many human solid tumors of diverse cellular origins. May be associated with B cell differentiation. Increased expression is associated with increased proliferation and invasive capacity in different cell types. May negatively regulate ATM protein levels. Isoform 2 is expressed in colon, breast, prostate, pancreas and kidney tumor cell lines. Isoform 2 is expressed at high levels in kidney, prostate, brain, small intestine and pancreas, at moderate levels in placenta and colon, at low levels in lung, liver and heart, and at very low levels in spleen, thymus, peripheral mononuclear blood cells, testis and ovary. Isoform 2 is expressed at lower levels in fetal brain and kidney than in adult brain and kidney. Eight isoforms of the human protein are produced by alternative splicing.

Byrne J.A., Cancer Res. 55:2896-2903(1995).
Olsen J.V., Cell 127:635-648(2006).
Molina H., Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).

References:

appl_detail:

Immunohistochemistry: 1:50~1:100

Datasheet PDF