EPHB4 Antibody

Catalog Number:

33819

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P54760
NCBI Gene ID: 2050

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human EPHB4.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total EPHB4 protein.

Applications:

WB

Background:

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.

Bennett B.D., J. Biol. Chem. 269:14211-14218(1994).
Wilson M.D., Nucleic Acids Res. 29:1352-1365(2001).
Zhang Y., Mol. Cell. Proteomics 4:1240-1250(2005).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF