MAT1 Antibody

Catalog Number:

33801

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P51948
NCBI Gene ID: 4331

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human MAT1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total MAT1 protein.

Applications:

WB

Background:

Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.

Tassan J.-P., EMBO J. 14:5608-5617(1995).
Yee A., Cancer Res. 55:6058-6062(1995).
Tirode F., Mol. Cell 3:87-95(1999).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF