AATF Antibody

Catalog Number:

34082

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9NY61
NCBI Gene ID: 26574

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from N-terminal of human AATF.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total AATF protein.

Applications:

WB

Background:

May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.

Lindfors K., Biochem. Biophys. Res. Commun. 276:660-666(2000).
Fanciulli M., FASEB J. 14:904-912(2000).
Di Padova M., J. Biol. Chem. 278:36496-36504(2003).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF