CKI-ε Antibody

Catalog Number:

33782

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P49674
NCBI Gene ID: 1454

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human CKI-ε.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CKI-ε protein.

Applications:

WB IHC IF

Background:

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.

Fish K.J., J. Biol. Chem. 270:14875-14883(1995).
Okamura A., Blood 103:2997-3004(2004).
Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004).

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500

Datasheet PDF