CUTL1 Antibody

Catalog Number:

33764

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P39880
NCBI Gene ID: 1523

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from N-terminal of human CUTL1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CUTL1 protein.

Applications:

WB

Background:

Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator By similarity.

Neufeld E.J., Nat. Genet. 1:50-55(1992).
Gloeckner G., Genome Res. 8:1060-1073(1998).
Rong Zeng W., Gene 241:75-85(2000).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF