ACVL1 Antibody

Catalog Number:

33762

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P37023
NCBI Gene ID: 94

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human ACVL1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total ACVL1 protein.

Applications:

WB IHC IF

Background:

Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.

ten Dijke P., Oncogene 8:2879-2887(1993).
Attisano L., Cell 75:671-680(1993).
Berg J.N., Am. J. Hum. Genet. 61:60-67(1997).

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500

Datasheet PDF