HXK1 Antibody

Catalog Number:

33706

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P19367
NCBI Gene ID: 3098

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human HXK1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total HXK1 protein.

Applications:

WB

Background:

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein.

Nishi S., Biochem. Biophys. Res. Commun. 157:937-943(1988).
Ruzzo A., Biochem. J. 331:607-613(1998).
Deloukas P., Nature 429:375-381(2004).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF