ATF1 Antibody

Catalog Number:

33703

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P18846
NCBI Gene ID: 466

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human ATF1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total ATF1 protein.

Applications:

WB IF

Background:

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.

Yoshimura T., EMBO J. 9:2537-2542(1990).
Rehfuss R.P., J. Biol. Chem. 266:18431-18434(1991).
Hai T., Genes Dev. 3:2083-2090(1989).

References:

appl_detail:

Western blotting: 1:500~1:3000

Immunofluorescence: 1:100~1:500

Datasheet PDF