ATF7 Antibody

Catalog Number:

33695

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P17544
NCBI Gene ID: 11016

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human ATF7.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total ATF7 protein.

Applications:

WB

Background:

Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4/ATF-A0acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5/ATF-4acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.

Gaire M., Nucleic Acids Res. 18:3467-3473(1990).
Chatton B., Submitted (DEC-1990) to the EMBL/GenBank/DDBJ databases.
Olsen J.V., Cell 127:635-648(2006).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF