Adrenergic Receptor α-2A Antibody

Catalog Number:

33660

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P08913
NCBI Gene ID: 150

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human Adrenergic Receptor α-2A.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total Adrenergic Receptor α-2A protein.

Applications:

WB IHC IF

Background:

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.

Kobilka B.K., Science 238:650-656(1987).
Fraser C.M., J. Biol. Chem. 264:11754-11761(1989).
Guyer C.A., J. Biol. Chem. 265:17307-17317(1990).

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500

Datasheet PDF