MEKKK 4 Antibody

Catalog Number:

33638

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: O95819
NCBI Gene ID: 9448

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human MEKKK 4.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total MEKKK 4 protein.

Applications:

WB IF

Background:

Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.

Yao Z., J. Biol. Chem. 274:2118-2125(1999).
Wright J.H., Mol. Cell. Biol. 23:2068-2082(2003).
Ishikawa K., DNA Res. 5:169-176(1998).

References:

appl_detail:

Western blotting: 1:500~1:3000

Immunofluorescence: 1:100~1:500

Datasheet PDF