JHD3B Antibody

Catalog Number:

33623

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: O94953
NCBI Gene ID: 23030

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from C-terminal of human JHD3B.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total JHD3B protein.

Applications:

IHC

Background:

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.

Nagase T., DNA Res. 5:355-364(1998).
Nakajima D., DNA Res. 9:99-106(2002).
Grimwood J., Nature 428:529-535(2004).

References:

appl_detail:

Immunohistochemistry: 1:50~1:100

Datasheet PDF