EFNA2 Antibody

Catalog Number:

33591

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: O43921
NCBI Gene ID: 1943

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from Internal of human EFNA2.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total EFNA2 protein.

Applications:

WB

Background:

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis By similarity.

Cerretti D.P., Genomics 47:131-135(1998).
Aasheim H.C., Biochem. Biophys. Res. Commun. 252:378-382(1998).
Grimwood J., Nature 428:529-535(2004).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF