PDZD2 Antibody

Catalog Number:

33574

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: O15018
NCBI Gene ID: 23037

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human PDZD2.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total PDZD2 protein.

Applications:

IHC IF

Background:

Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis.

Chaib H., Cancer Res. 61:2390-2394(2001).
Nagase T., DNA Res. 4:141-150(1997).

References:

appl_detail:

Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500

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