IF2B3 Antibody

Catalog Number:

33560

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: O00425
NCBI Gene ID: 10643

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from N-terminal of human IGF2BP3.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total IGF2BP3 protein.

Applications:

WB

Background:

RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.

Mueller-Pillasch F., Oncogene 14:2729-2733(1997).
Bechtel S., BMC Genomics 8:399-399(2007).
Hillier L.W., Nature 424:157-164(2003).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF