TR11B Antibody

Catalog Number:

33557

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: O00300
NCBI Gene ID: 4982

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from Internal of human TR11B.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total TR11B protein.

Applications:

WB

Background:

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

Simonet W.S., Cell 89:309-319(1997).
Yasuda H., Endocrinology 139:1329-1337(1998).
Morinaga T., Eur. J. Biochem. 254:685-691(1998).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF