TR10A Antibody

Catalog Number:

33555

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: O00220
NCBI Gene ID: 8797

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from C-terminal of human TR10A.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total TR10A protein.

Applications:

WB

Background:

Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.

Pan G., Science 276:111-113(1997).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Chaudhary P.M., Immunity 7:821-830(1997).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF