Ubiquitin Antibody

Catalog Number:

33537

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P62988
NCBI Gene ID: 7311

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from Internal of human Ubiquitin.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total ubiquitin protein.

Applications:

IHC

Background:

Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome.

John Hanna, Mol. Cell. Biol., Dec 2003; 23: 9251 - 9261.
Matthias Majetschak, Blood, Mar 2003; 101: 1882 - 1890.
Fu Shang, J. Biol. Chem., May 2005; 280: 20365 - 20374.
Joerg Herrmann, Circ. Res., May 2007; 100: 1276 - 1291.

References:

appl_detail:

Immunohistochemistry: 1:50~1:100

Datasheet PDF