TIMP1 Antibody

Catalog Number:

33502

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P01033
NCBI Gene ID: 7076

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human TIMP1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total TIMP1 protein.

Applications:

WB

Background:

Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.

Anieta M. Sieuwerts, Clin. Chem., May 2007; 10.1373.
KM Fong, Clin. Cancer Res., Aug 1996; 2: 1369.
E. Susol, Rheumatology, Dec 2000; 39: 1332 - 1336.
Christopher J Jackson, Ann Rheum Dis, Mar 1998; 57: 158 - 161.

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF