Retinoic Acid Receptor β Antibody

Catalog Number:

33480

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P10826
NCBI Gene ID: 5915

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human Retinoic Acid Receptor β.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total Retinoic Acid Receptor β protein.

Applications:

WB IHC

Background:

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.

Reuben Lotan, N. Engl. J. Med., May 1995; 332: 1405 - 1411.
Andrew Yen, Mol. Pharmacol., Dec 2004; 66: 1727 - 1737.
K Swisshelm, Cell Growth Differ., Feb 1994; 5: 133.
F Aoudjit, Cell Growth Differ., May 1995; 6: 515.

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Datasheet PDF