Presenilin 1 Antibody

Catalog Number:

33474

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P49768
NCBI Gene ID: 5663

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human presenilin 1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total presenilin 1 protein.

Applications:

WB IHC

Background:

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.

Yanzhu Liu, J. Lipid Res., Dec 2004; 45: 2368 - 2376.
I. Imafuku, J. Cell Biol., Oct 1999; 147: 121.
Angeliki Louvi, Development, Jul 2004; 131: 3093 - 3105.
Wim G. Annaert, J. Cell Biol., Oct 1999; 147: 277.

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Datasheet PDF