p63 Antibody

Catalog Number:

33462

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9H3D4
NCBI Gene ID: 8626

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human p63 antibody.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total p63 protein.

Applications:

WB IF

Background:

Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specificactivity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.

Pranay C. Patel, Arch Otolaryngol Head Neck Surg, May 1998; 124: 559.
Atul A. Gawande, Arch Surg, Apr 2006; 141: 381 - 384.
Timothy M. Murray, Endocr. Rev., Feb 2005; 26: 78 - 113.
W. M. Philbrick, Physiol Rev, Jan 1996; 76: 127.

References:

appl_detail:

Western blotting: 1:500~1:3000

Immunofluorescence: 1:100~1:500

Datasheet PDF