MMP-2 Antibody

Catalog Number:

33441

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P08253
NCBI Gene ID: 4313

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human MMP-2.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total MMP-2 protein.

Applications:

WB

Background:

Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels. Isoform 2:Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.

Charlotte J. Morrison, J. Biol. Chem., Dec 2001; 276: 47402 - 47410.
Hala S. Azzam, J Natl Cancer Inst, Nov 1993; 85: 1758 - 1764.
Jane L. English, J. Biol. Chem., Apr 2006; 281: 10337 - 10346.
JORDI ESPARZA, FASEB J, Nov 2004; 18: 1682 - 1691.

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF