Keratin 5 Antibody

Catalog Number:

33419

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P13647
NCBI Gene ID: 3852

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human Keratin 5.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total Keratin 5 protein.

Applications:

WB IHC

Background:

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

Bettina Peters, Mol. Biol. Cell, Jun 2001; 12: 1775.
J Casatorres, J. Biol. Chem., Aug 1994; 269: 20489 - 20496.
Karin M¨¹ller-Decker, Am. J. Pathol., Feb 2005; 166: 575 - 584.
Angel Ram¨ªrez, Genetics, May 2001; 158: 341.

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Datasheet PDF