Keratin 17 Antibody

Catalog Number:

33415

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q04695
NCBI Gene ID: 3872

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human keratin 17.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total keratin 17 protein.

Applications:

WB IHC IF

Background:

May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair By similarity.

M Rosenberg, Mol. Cell. Biol., Feb 1988; 8: 722 - 736.
SM Troyanovsky, J. Cell Sci., Jul 1989; 93: 419.
Kevin M. McGowan, Genes & Dev., Jun 2002; 16: 1412.
Nicholas Bianchi, Mol. Cell. Biol., Aug 2005; 25: 7249 - 7259.

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500

Datasheet PDF