JAB1 Antibody

Catalog Number:

33411

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9UNS2
NCBI Gene ID: 8533

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human JAB1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total JAB1 protein.

Applications:

WB IF

Background:

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

George Z. Rassidakis, Clin. Cancer Res., Mar 2003; 9: 1121.
Ricardo V. Lloyd, Am. J. Pathol., Mar 2002; 160: 1171.
Shu Xiao, PNAS, Oct 2006; 103: 16448 - 16453.
Alex Kudrin, J. Biol. Chem., Oct 2006; 281: 29641 - 29651.

References:

appl_detail:

Western blotting: 1:500~1:3000

Immunofluorescence: 1:100~1:500

Datasheet PDF