HDAC9 Antibody

Catalog Number:

33403

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9UKV0
NCBI Gene ID: 9734

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human HDAC9.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total HDAC9 protein.

Applications:

WB IHC IF

Background:

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.

Michael Haberland, Mol. Cell. Biol., Jan 2007; 27: 518 - 525.
Xianbo Zhou, PNAS, Sep 2001; 98: 10572.
Kevin Petrie, J. Biol. Chem., Apr 2003; 278: 16059 - 16072.
Kevin Petrie, Blood (ASH Annual Meeting Abstracts), Nov 2004; 104: 1120.

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500

Datasheet PDF