HDAC7 Antibody

Catalog Number:

33402

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q8WUI4
NCBI Gene ID: 51564

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human HDAC7.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total HDAC7 protein.

Applications:

WB IHC

Background:

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors By similarity. May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene.

Maribel Parra, Genes & Dev., Mar 2007; 21: 638 - 643.
Wolfgang Fischle, J. Biol. Chem., Sep 2001; 276: 35826 - 35835.
Maribel Parra, J. Biol. Chem., Apr 2005; 280: 13762 - 13770.
Uwe Dressel, J. Biol. Chem., May 2001; 276: 17007 - 17013.

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Datasheet PDF