HDAC5 Antibody

Catalog Number:

33401

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9UQL6
NCBI Gene ID: 10014

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human HDAC5.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total HDAC5 protein.

Applications:

WB IHC IF

Background:

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors.

Claudie Lemercier, J. Biol. Chem., May 2000; 275: 15594.
Carmen C. Sucharov, Am J Physiol Cell Physiol, Nov 2006; 291: C1029 - C1037.
Michael P. Czubryt, PNAS, Feb 2003; 100: 1711.
changhoon ha, FASEB J, Apr 2007; 21: A528.

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500

Datasheet PDF