Guanylate Cyclase β Antibody

Catalog Number:

33396

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q02153
NCBI Gene ID: 2983

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human Guanylate Cyclase β.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total Guanylate Cyclase β protein.

Applications:

WB IHC IF

Background:

This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants.

A. Shimouchi, Am J Physiol Lung Cell Mol Physiol, Nov 1993; 265: 456.
Peter Sinnaeve, Circ. Res., Jan 2001; 88: 103.
Stephan Thelitz, J. Thorac. Cardiovasc. Surg., May 2004; 127: 1285 - 1292.
Richard C. Venema, Am J Physiol Heart Circ Physiol, Jul 2003; 2

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Datasheet PDF