Catenin-γ Antibody

Catalog Number:

33330

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P14923
NCBI Gene ID: 3728

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human Catenin-γ.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total Catenin-γ protein.

Applications:

WB IHC

Background:

Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton By similarity.

T Naka, J. Clin. Pathol., Dec 2001; 54: 945 - 950.
AR Burns, J. Immunol., Sep 1997; 159: 2893.
Frank T. Kolligs, Genes & Dev., Jun 2000; 14: 1319.
Jon A. Ukropec, J. Biol. Chem., Feb 2000; 275: 5983.

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Datasheet PDF